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Gamblecode > Blog > Guides & Strategies > NFL Betting Guide and Picks Revealed

NFL Betting Guide and Picks Revealed

The team By The team 1 October 2025 5 Min Read
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NFL Betting Guide and Picks Revealed
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Introduction to Week 5 NFL Picks

There are several interesting quarterback matchups on Sunday that could add some spice to your Week 5 NFL picks. QBs who’ve had more success since leaving New York, in Geno Smith and Daniel Jones, meet in Raiders vs. Colts (-6.5). A pair of former Alabama signal callers in Tua Tagovailoa and Bryce Young square off in Dolphins vs. Panthers (+1.5), while No. 1 picks in Cam Ward and Kyler Murray meet in Titans vs. Cardinals (-7.5).

Contents
Introduction to Week 5 NFL PicksWeek 5 NFL Betting GuideNFL Picks and ParlaysNFL Parlay PicksNFL DFS PicksFantasy RankingsAdvanced NFL ModelNFL Vegas Expert PicksGame-Specific PicksConclusion

Week 5 NFL Betting Guide

A Week 5 NFL betting guide would help identify the NFL lines to target with your picks, either for these matchups or others. Nine games have a spread of 3.5 points or fewer, per the latest Week 5 NFL odds, which could be a plus or a negative to football bettors. Whether you prefer targeting narrow spreads or wide ones, your Week 5 NFL betting strategy should leave no stone unturned.

NFL Picks and Parlays

If you are looking for NFL picks, NFL parlays, Fantasy football rankings or NFL DFS picks for Week 5, SportsLine has you covered with its proven model, Machine Learning Model and team of experts. SportsLine’s model has returned well over $7,000 on top-rated NFL betting picks since its inception, so those picks can confidently be used to fill out NFL parlay picks on betting apps.

NFL Parlay Picks

The model has built a five-team parlay for Week 5 that pays 25-1, and one of the legs is the Minnesota Vikings (-3.5, 36.5) covering against the Browns in London. The model has Minnesota covering in almost 60% of simulations, and the rest of the five-team parlay can be found here.

NFL DFS Picks

SportsLine has a DFS Optimizer that simulates every game 10,000 times and uses info from the SportsLine Projection Model and DFS Professional Millionaire Mike McClure to identify top DFS picks/plays for any slate on sites like FanDuel and DraftKings. It has the Jets’ Garrett Wilson as one of its top value picks at receiver, while Miami’s Darren Waller is among the best values at tight end for Sunday’s main slate.

Fantasy Rankings

Senior Fantasy Writer Heath Cummings has locked in his projections for every Fantasy relevant quarterback, running back, wide receiver and tight end in your leagues. Not only do you get statistical projections as well as Fantasy point totals for every player in different scoring formats, but Cummings also includes DFS prices and values to help build winning DFS lineups each week.

Advanced NFL Model

SportsLine’s model simulates every game 10,000 times, which has helped it produce better Fantasy rankings than human experts over the last few seasons. It has revealed its Week 5 Fantasy football rankings that can be used to make start-sit decisions. Indianapolis’ Daniel Jones is projected to be a top-5 Fantasy quarterback this week, and the model also has full rankings for every position.

NFL Vegas Expert Picks

SportsLine has an expansive team of NFL experts who provide quality betting advice for every game on the schedule. Analyst Todd Fuhrman, who is on an 8-2 roll (+593) over his last 10 NFL picks, has revealed his best bets for Week 5. He is backing the Texans (+1.5) to cover on the road versus the Ravens.

Game-Specific Picks

The Rams will host the 49ers in a matchup of 3-1 teams on Thursday Night Football. The Rams have won three straight meetings with the Niners, but San Francisco has prevailed in five of its last six regular season trips to Los Angeles to face its divisional rival. The Bills will host the Patriots on Sunday Night Football, and the Chiefs will seek their ninth straight win over the Jaguars on Monday Night Football.

Conclusion

In conclusion, Week 5 of the NFL season is shaping up to be an exciting one, with several interesting quarterback matchups and closely contested games. Whether you’re looking for NFL picks, parlays, Fantasy football rankings, or DFS picks, SportsLine has you covered with its proven model and team of experts. With the help of these resources, you can make informed decisions and increase your chances of winning.

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