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Gamblecode > Blog > News & Trends > 2025 NFL Week 2 Predictions

2025 NFL Week 2 Predictions

The team By The team 10 September 2025 4 Min Read
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2025 NFL Week 2 Predictions

Introduction to NFL Week 2

The NFL lineup in Week 2 is expected to provide some exciting matchups, including the Philadelphia Eagles versus the Kansas City Chiefs. For those interested in betting, here’s a rundown of the odds and predictions for each game.

Contents
Introduction to NFL Week 2Week 2 Betting Lines & Game InfoGreen Bay Packers vs. Washington CommandersNew York Jets vs. Buffalo BillsPittsburgh Steelers vs. Seattle SeahawksOther Notable MatchupsSunday Night Football and BeyondMonday Night FootballConclusion

Week 2 Betting Lines & Game Info

The week starts with the Green Bay Packers vs. Washington Commanders, with the Packers favored to win by 3.5 points. Other notable matchups include the New York Jets vs. Buffalo Bills, Pittsburgh Steelers vs. Seattle Seahawks, and Cincinnati Bengals vs. Jacksonville Jaguars.

Green Bay Packers vs. Washington Commanders

  • Spread: Packers (-3.5)
  • Moneyline: Packers -184, Commanders +153
  • Total: 48 points
  • Prediction: Packers 28, Commanders 22
  • Game Date: Thursday, Sept. 11
  • Game Time: 8:15 p.m. ET
  • TV Channel: Amazon Prime Video
  • Location: Green Bay, Wisconsin

New York Jets vs. Buffalo Bills

  • Spread: Bills (-6.5)
  • Moneyline: Bills -319, Jets +256
  • Total: 46 points
  • Prediction: Bills 31, Jets 17
  • Game Date: Sunday, Sept. 14
  • Game Time: 1 p.m. ET
  • TV Channel: CBS
  • Location: East Rutherford, New Jersey

Pittsburgh Steelers vs. Seattle Seahawks

  • Spread: Steelers (-3)
  • Moneyline: Steelers -157, Seahawks +132
  • Total: 40 points
  • Prediction: Steelers 22, Seahawks 21
  • Game Date: Sunday, Sept. 14
  • Game Time: 1 p.m. ET
  • TV Channel: FOX
  • Location: Pittsburgh, Pennsylvania

Other Notable Matchups

  • Cincinnati Bengals vs. Jacksonville Jaguars: Bengals (-3.5), Moneyline: Bengals -182, Jaguars +152, Total: 49.5 points, Prediction: Bengals 30, Jaguars 18
  • Miami Dolphins vs. New England Patriots: Dolphins (-1.5), Moneyline: Dolphins -120, Patriots +101, Total: 43.5 points, Prediction: Dolphins 25, Patriots 16
  • Dallas Cowboys vs. New York Giants: Cowboys (-5.5), Moneyline: Cowboys -260, Giants +211, Total: 44.5 points, Prediction: Cowboys 26, Giants 18
  • Detroit Lions vs. Chicago Bears: Lions (-5.5), Moneyline: Lions -256, Bears +209, Total: 47.5 points, Prediction: Lions 35, Bears 12

Sunday Night Football and Beyond

  • New Orleans Saints vs. San Francisco 49ers: 49ers (-4.5), Moneyline: 49ers -224, Saints +184, Total: 42.5 points, Prediction: 49ers 24, Saints 23
  • Tennessee Titans vs. Los Angeles Rams: Rams (-5.5), Moneyline: Rams -248, Titans +202, Total: 42 points, Prediction: Rams 28, Titans 16
  • Baltimore Ravens vs. Cleveland Browns: Ravens (-11.5), Moneyline: Ravens -775, Browns +536, Total: 45 points, Prediction: Ravens 36, Browns 10

Monday Night Football

  • Houston Texans vs. Tampa Bay Buccaneers: Texans (-2.5), Moneyline: Texans -144, Buccaneers +121, Total: 42.5 points, Prediction: Buccaneers 26, Texans 22
  • Las Vegas Raiders vs. Los Angeles Chargers: Chargers (-3.5), Moneyline: Chargers -187, Raiders +156, Total: 47 points, Prediction: Chargers 26, Raiders 17

Conclusion

Week 2 of the NFL promises to be an exciting weekend with several closely contested matchups. From the opening game between the Packers and Commanders to the Monday night fixtures, there’s something for every football fan. Whether you’re into betting or just enjoying the games, this week’s lineup has the potential to deliver some thrilling football.

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